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A key switch for cellular energy balance has been discovered in cells: it could potentially become the target of new therapies for diseases ranging from Parkinson’s to rare disorders caused by defects in the cell’s powerhouses, the mitochondria. The switch is called phosphatase B55 (PP2A-B55alpha) and regulates the balance of mitochondria. Experts from Università Cattolica,…

A higher weekly dose of semaglutide (7.2 mg) can significantly improve weight loss and related health outcomes in adults living with obesity, including those with type 2 diabetes (T2D), according to the results of two large-scale, international phase 3 clinical trials. The findings, published in The Lancet Diabetes & Endocrinology journal, suggest that a higher…

Drinking any amount of alcohol likely increases the risk of dementia, suggests the largest combined observational and genetic study to date, published online in BMJ Evidence Based Medicine. Even light drinking — generally thought to be protective, based on observational studies — is unlikely to lower the risk, which rises in tandem with the quantity…

The habitat of thirty species of sharks, rays, and chimaeras, also called ghost sharks, overlap with areas where proposed deep-sea mining may occur, according to new research published in Current Biology and led by University of Hawai’i at Mānoa oceanographers. Nearly two-thirds of these species are already threatened with extinction due to human impacts, so…

Mark PoyntingClimate and science reporter, BBC News BBC When Matthias Huss first visited Rhône Glacier in Switzerland 35 years ago, the ice was just a short walk from where his parents would park the car. “When I first stepped onto the ice… there [was] a special feeling of eternity,” says Matthias. Today, it’s half an…